Posts Tagged "NSAIDs"

NAIDS 2Regularly taking low-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may lower long-term risk of colorectal cancer (CRC), new research suggests. The study was published online August 25 in the Annals of Internal Medicine.

John Baron, MD, a professor of medicine at the University of North Carolina School of Medicine in Chapel Hill, and colleagues reviewed data from several Danish cancer databases to gather the health histories of 10,280 CRC patients diagnosed between 1994–2011. Patients were between the ages of 30–85. Medical records were evaluated for aspirin and non-aspirin NSAID consumption patterns.

A comparison of cancer patients with 102,800 cancer-free individuals revealed that regular, long-term use of low-NAIDSdose aspirin and NSAIDs seemed to confer long-term protection against CRC. The biggest benefit was linked to agents with high cyclooxygenase-2 selectivity. Taking low-dose (75–150mg) aspirin for five years or more was associated with a 27% risk reduction in both men and women. And taking NSAIDs such as ibuprofen for that long was linked to a 30–45% drop in CRC risk.

Baron emphasized that the drugs were taken continuously for years before any cancer-preventive benefits were realized. “For aspirin, you would have to take it fairly consistently, meaning at least every other day, for at least five to 10 years for the protective effect to even begin to appear,” he told HealthDay.

Source: MPR

The Center’s Executive Physical includes Colon and Rectal Cancer screening and tumor marker tracking.

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A study at the National Cancer Institute (NCI) has shown that women who take aspirin daily may reduce their risk of ovarian cancer by 20%. Prior research has suggested that the anti-inflammatory properties of aspirin and non-aspirin NSAIDs may reduce overall risk of cancer, but studies specific to ovarian cancer have been inconclusive. This is the largest study to date on risk reduction in ovarian cancer and these medications. Britton Trabert, PhD, and Nicolas Wentzensen, MD, PhD, and their colleagues from NCI’s Division of Cancer Epidemiology and Genetics examined data from 12 large epidemiological studies (9 from the US) of nearly 8,000 women with ovarian cancer and close to 12,000 women without ovarian cancer. Eighteen percent reported that they used aspirin, 24% used non-aspirin NSAIDs, and 16% used acetaminophen. Daily aspirin users had a 20% lower risk of ovarian cancer compared to those who took it less than once a week. Women who reported using NSAIDs at least once a week showed a reduction in risk that was not statistically significant, and acetaminophen was not associated with a reduction in ovarian cancer risk.

Source: MPR

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